From The Collaborative International Dictionary of English v.0.48 [gcide]:
2. (Physiol.) The irritating action of various agents (stimuli) on muscles, nerves, or a sensory end organ, by which activity is evoked; especially, the nervous impulse produced by various agents on nerves, or a sensory end organ, by which the part connected with the nerve is thrown into a state of activity; irritation.
From WordNet (r) 3.0 (2006) [wn]:
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