From The Collaborative International Dictionary of English v.0.48 [gcide]:
1. The act of irritating, or exciting, or the state of being irritated; excitement; stimulation, usually of an undue and uncomfortable kind; especially, excitement of anger or passion; provocation; annoyance; anger.
2. (Physiol.) The act of exciting, or the condition of being excited to action, by stimulation; -- as, the condition of an organ of sense, when its nerve is affected by some external body; esp., the act of exciting muscle fibers to contraction, by artificial stimulation; as, the irritation of a motor nerve by electricity; also, the condition of a muscle and nerve, under such stimulation.
From WordNet (r) 3.0 (2006) [wn]:
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