From The Collaborative International Dictionary of English v.0.44 [gcide]:
1. The act of irritating, or exciting, or the state of being irritated; excitement; stimulation, usually of an undue and uncomfortable kind; especially, excitement of anger or passion; provocation; annoyance; anger.
2. (Physiol.) The act of exciting, or the condition of being excited to action, by stimulation; -- as, the condition of an organ of sense, when its nerve is affected by some external body; esp., the act of exciting muscle fibers to contraction, by artificial stimulation; as, the irritation of a motor nerve by electricity; also, the condition of a muscle and nerve, under such stimulation.
From WordNet (r) 2.0 [wn]:
From Moby Thesaurus II by Grady Ward, 1.0 [moby-thes]:
100 Moby Thesaurus words for "irritation": adverse circumstances, adversity, affliction, aggravation, agitation, algesia, amplification, animation, annoyance, arousal, arousing, augmentation, blight, bummer, care, chafe, contentiousness, cross, curse, deepening, deliberate aggravation, deterioration, difficulties, difficulty, disapprobation, disapproval, discontent, displeasure, dissatisfaction, downer, electrification, embittering, embitterment, enhancement, enlargement, exacerbation, exasperation, excitation, excitement, exhilaration, festering, firing, fomentation, fret, gall, galvanization, hard knocks, hard life, hard lot, hardcase, hardship, heightening, incitation, incitement, increase, inflammation, infuriation, instigation, intensification, irritant, lathering up, magnification, pep rally, pep talk, perturbation, plight, predicament, pressure, provocation, rabble-rousing, rankling, resentfulness, resentment, rigor, sea of troubles, sensitiveness, sharpening, sore, sore spot, soreness, souring, steaming up, stimulation, stimulus, stirring, stirring up, stirring-up, stress, stress of life, tenderness, trial, tribulation, trouble, troubles, vale of tears, vexation, vicissitude, whipping up, working up, worsening
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