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From The Collaborative International Dictionary of English v.0.44 [gcide]:
Insignificance \In'sig*nif"i*cance\, noun
1. The condition or quality of being insignificant; lack of significance, sense, or meaning; as, the insignificance of words or phrases.
2. Lack of force or effect; unimportance; pettiness; inefficacy; as, the insignificance of human art.
3. Lack of claim to consideration or notice; lack of influence or standing; meanness.
Reduce him, from being the first person in the nation, to a state of insignificance. --Beattie.
From WordNet (r) 2.0 [wn]:
insignificance
noun: the quality of having little or no significance [ant: {significance}]
From Moby Thesaurus II by Grady Ward, 1.0 [moby-thes]:
53 Moby Thesaurus words for "insignificance": aimlessness, daintiness, dead letter, delicacy, diminutiveness, emptiness, empty sound, exiguity, exiguousness, fewness, futility, immateriality, inanity, inconsequence, inconsequentiality, inconsiderableness, indifference, ineffectuality, inferiority, insufficiency, irrelevance, littleness, low priority, marginality, meagerness, meaninglessness, meanness, mere noise, minuteness, moderateness, negligibility, noise, nonsensicality, nullity, pettiness, phatic communion, picayune, picayunishness, pokiness, puniness, purposelessness, scantiness, secondariness, senselessness, slightness, smallness, tininess, triviality, unimportance, unimpressiveness, unmeaningness, unnoteworthiness, unsignificancy
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