2 definitions found From WordNet (r) 2.0 [wn]: despondence noun: feeling downcast and disheartened and hopeless [syn: {despondency}, {heartsickness}, {disconsolateness}] From The Collaborative International Dictionary of English v.0.44 [gcide]: Despondence \De*spond"ence\, noun Despondency. The people, when once infected, lose their relish for happiness [and] saunter about with looks of despondence. --Goldsmith.

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